Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and s

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：zhangtianyu66

【摘要】

：

　　DNA-dependent protein kinase catalytic subunit(DNA-PKcs)plays a critical role in non-homologous end joining(NHEJ)of DNA double-stand break(DSB)repair.Previo

【作者】

：

Liu Xiongxiong Li Qiang

【机构】

：

InstituteofModernPhysics,ChineseAcademyofSciences,Lanzhou730000

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

Genistein DNA-PKcs DSB repair

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　　DNA-dependent protein kinase catalytic subunit(DNA-PKcs)plays a critical role in non-homologous end joining(NHEJ)of DNA double-stand break(DSB)repair.Previously,we found genistein could sensitize cancer cells to low linear energy transfer(LET)X-rays via inhibiting DNA-PKcs activities.Especially,high-LET heavy ion produces more DNA DSBs than low-LET radiation.

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Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and s

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