【摘 要】
：
In our research program of discovering novel bioactive natural products, more than sixty novel compounds, including seven kinds of unprecedented carbon skeletons, were isolated from six common used TC
【出 处】
：
世界中医药学会联合会中药化学专业委员会第五届学术年会暨蒙医药论坛
论文部分内容阅读
In our research program of discovering novel bioactive natural products, more than sixty novel compounds, including seven kinds of unprecedented carbon skeletons, were isolated from six common used TCMs from Zingiberaceae family.Their structures, belonging to sesquiterpene-chalcone conjugates, rearranged labdane norditerpenoids, chalcone-diarylheptanoid adducts, normal sesquiterpene and diterpenoid, were elucidated by extensive NMR and HRMS spectra analyses.The absolute configuration of some complex compounds were determined by moshers method, X-ray single crystal diffraction, and ECD calculation.Six novel isolates were selected as the "Hot off the Press" in journal " Natural Product Reports", two of which were synthesized by other groups soon after published.Besides the isolation and structural elucidation,bioactivity of the most compounds was evaluated, and some of them exhibited pronounced anti-tumor, cytotoxicity, and anti-inflammatory.
其他文献
目的：对小叶莲药材的化学成分进行研究.方法：利用Sephadex LH-20柱色谱、ODS柱色谱、硅胶柱色谱进行分离纯化,通过理化常数和波谱分析技术进行结构鉴定.结果：从小叶莲药材中分离得到10个化合物,分别鉴定为5-羟基麦芽酚(5-oxymaltol)(Ⅰ)、对羟基苯甲酸(p-hydroxybenic acid)(Ⅱ)、香草酸(vanillic acid)(Ⅲ)、2,4,6-三羟基苯甲酸乙酯(E
目的：对博落回(Macteaya cordata(Willd.)R.B r.)中苯并菲啶类生物碱外消旋体进行分离鉴定.方法：采用硅胶柱色谱、氧化铝、ODS、Sephadex LH-20柱色谱和制备高效液相色谱、制备薄层色谱、手性液相色谱等方法对博落回地上部分乙醇提取物进行分离纯化,通过1D、2D NMR、UV、IR、X-单晶衍射及计算ECD等方法对化合物进行结构鉴定.结果：从博落回乙醇提取物中分离
目的：应用UPLC-MS/MS方法分析知母中的甾体皂苷成分.方法：采用Waters UPLC HSS T3(2.1×150mm,1.8μm)色谱柱及HSS T3(2.1×5mm,1.8μm)预柱.流动相：A相10mmol甲酸铵和0.1％甲酸水溶液;B相0.1％甲酸乙腈溶液.4000-Qtrap检测器,ESI离子源,正离子模式下采集[M+NH4]+数据.结果：总结了6个甾体皂苷标准品正离子模式下的二
目的：研究野葛Pueraria lobata干燥根的化学成分.方法：进一步研究野葛Pueraria lobata干燥根的化学成分,根据化合物的理化性质和波谱数据鉴定其结构.方法：采用硅胶柱色谱法结合制备高效液、Sephadex LH-20柱层析进行分离和纯化.结果：分离并鉴定了7个化合物;1-(2-hydroxy-4-(β-D-glucopyranosyl)oxy-phenyl)-2-(4-hyd
Hirudo (Shuizhi in Chinese) is an important Chinese medicine, which possesses many therapeutic properties for the treatment of the cerebral hemorrhage and other thrombosis-related diseases.The phytoch
Three new flavonoid derivatives, perifolins A-C (1-3), along with six known analogues 8-hydroxy-5,7-dimethoxyflavanone (4), apigenin (5), luteolin (6), negletein (7), scutellarein (8),and scutellarin
Two new annonaceous acetogenins, 12,15-cis-cis-squamostatin-A (1) and squamostatin-G (2) were isolated from the seeds of Annona squamosa.The structures of all of the isolates were established and char
目前认为中药进入体内的化合物，包括可吸收的原形成分及其代谢产物应该是中药发挥药效的物质来源，而其中能显示药效的化合物形式称其为"显效形式"[1]。本文将以中药土茯苓研究为例，探讨中药药效物质本质及其作用机制。土茯苓含有众多活性成分，口服后这些成分"可否吸收入血？在体内会发生什么变化？在体内是否起效，起效是以原形成分还是代谢产物的形式？"等问题需要阐明。本文企图发现土茯苓体内具有活性的原形成分和代谢
A new ent-kaurane diterpenoid glycoside, 7β,16α,17-trihydroxy-ent-kauran-19-oic acid 19-O-β-D-glucopyranoside ester (1), was isolated from the n-butyl alcohol-soluble fraction of ethanol extract of dr
Aims/hypothesis Pan-peroxisome proliferator-activated receptor (PPAR) agonists have long been sought as therapeutics against the metabolic syndrome, but current PPAR agonists show limited efficacy and