【摘 要】
：
This work was to investigate the balance of Th1/Th2 and Th17/Treg cells and the expressions of specific transcription factors in patients with immune thrombocytopenia(ITP)in Chinese population.Forty p
【机 构】
：
XiyuanHospital,ChinaAcademyofChineseMedicalSciences
【出 处】
：
世界中医药学会联合会血液病专业委员会第三届学术年会暨天津中西医结合学会血液病专业委员会2018学术年会
论文部分内容阅读
This work was to investigate the balance of Th1/Th2 and Th17/Treg cells and the expressions of specific transcription factors in patients with immune thrombocytopenia(ITP)in Chinese population.Forty patients with ITP and twenty healthy volunteers as the normal controls were recruited for the study.We measured the numbers of Th1,Th2,Th17 and Treg cells by flow cytometry,the expression levels of IFN-γ,IL-4,IL-17A,and TGF-β by flow-based Multiple Immunoassays,and the expressions of T-bet,GATA-3,ROR-γ t,and Foxp3 by RT-PCR.The results showed that the expressions of IFN-γ in Th1 cells and the ratio of Th1/Th2 cells were significantly increased(P <0.05)in ITP group,while the expressions of IL-4 in Th2 cells and were significantly decreased(P <0.05).
其他文献
[目的]明确浙贝黄芩汤调控Wip1 对急性髓系白血病动物模型提高化疗缓解率及逆转耐药的作用.[方法]将上述课题组构建HL60 白血病模型，随机分为4 组：模型组、浙贝黄芩汤灌胃(中药)组、阿霉素腹腔注射(化疗)组、浙贝黄芩汤灌胃+阿霉素腹腔注射(中药+化疗)组.模型组灌胃等量蒸馏水；中药组灌胃浙贝黄芩汤(7.58g/d/kg)每天一次，化疗组腹腔注射盐酸阿柔比星(1mg/kg)隔日一次，中药+化疗
背景：侵袭性真菌病(IFD)是血液系统肿瘤患者及造干细胞移植(HSCT)受者常见感染并发症。随着现代化疗和造血干细胞移植术的开展,IFD 的发病率呈上升趋势。由于IFD 在临床上缺乏特异性症状和体征,诊断困难且延误治疗伴有较高的病死率,故国内外IFD 相关指南均推荐对临床上具有IFD 高危因素并伴有发热性嗜中性白细胞减少症(FN)患者采用经验性抗真菌治疗策略。然而,经验性抗真菌治疗存在过度医疗、诱
[目的]初步揭示Wip1 与白血病进程的相关性。方法 采集复发/难治急性髓系白血病患者、初诊/敏感急性髓系白血病患者、健康成年人3-5ml 外周血,提取中性粒细胞、单个核细胞的总RNA,应用定时定量PCR 检测Wip1、野生型p53 表达量,检测急性髓系白血病患者p53 热点突变情况。
恶性淋巴瘤以其较高的发病率及死亡率严重危害人类的生命健康及财产安全，由于该疾病本身的病理特点及治疗特点，淋巴瘤患者多处于免疫功能紊乱状态，感染是淋巴瘤治疗过程中常见的并发症，其相关病死率可达4％～21％。除引起致命风险外，感染还降低了患者的生活质量，增加了患者经济负担。而中医药以多成分、多途径、多靶点参与淋巴瘤患者化疗后的免疫重建，在防治感染、调节免疫力方面作用显著，也是中医中药的优势之一。芪银三
Objective:To explore the feasibility of establishing the diseasesyndrome combined animal model for immune thrombocytopenic purpura(ITP)without additional conditions.Methods: Three batches of data rela
[目的]观察加味槐花散联合糖皮质激素治疗血热肠风型紫癜风临床疗效。[方法]选择2015 年10 月至2017 年10 月期间我院收治的52 例合并腹型的混合型过敏性紫癜患者，采用随机方法设置观察组28 例和对照组24 例。对照组采用西医常规用药甲泼尼龙琥珀酸钠、西咪替丁、氯雷他定；观察组在常规用药的基础上服用加味槐花散，早晚温服各一次，日一剂。两组均治疗3 周左右，观察并记录两组患者的临床疗效、症
Herba Sarcandrae is a kind of traditional Chinese medicine,which is used for the treatment of various types of thrombocytopenia.Flavonoids are the main effective ingredient of Herba Sarcandrae.However
[目的]：以探索性因子分析法分析骨髓增生异常综合症(MDS)患者治疗过程中的中医临床症候分类,并探讨以小柴胡汤为代表的和法作为治疗大法治疗MDS 的中医理论依据。方法：在骨髓增生异常综合征患者常见的贫血、感染及出血症状及合并西药药物治疗基础上,将符合纳入标准的60 例骨髓增生异常综合征患者的常见临床症状进行统计,以20 个常见临床症状作为20 个变量,在20 个变量(症状)中取15 个出现频率在1
Background Southern China provinces have high incidence of thalassemia but sporadic cases can be found in northern China as well.Method Positive patients or carriers were analyzed from suspected thala
Introduction It was found that 70–80%of patients with myelodysplastic syndrome(MDS)have at least one mutation.Gene mutation and other molecular biological markers have been included in the guidelines