Yeast-Based Assays for High-Throughput Screening of Inhibitors of Coronavirus RNA Cap Guanine-N7 Met

来源 :第十届全国病毒学学术研讨会 | 被引量 : 0次 | 上传用户:sunplusit
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  The 5-cap structure is a distinct feature of eukaryotic mRNAs, which is important for RNA stability and protein translation and provides a molecular signature for the distinction of self or non-self mRNA.Eukaryotic viruses generally modify the 5-end of viral RNAs to mimic cellular mRNA structure to support viral replications in host cells.
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