Does improved glucose control lower cardiovascular risk?A research with mini network balance model i

来源 :2015第11届全国药物和化学异物代谢学术会议 | 被引量 : 0次 | 上传用户：lollio

【摘要】

：

Objective: Cardiovascular events still occupy the first cause of mortality in type 2 diabetes mellitus (T2DM), which comes down to the metabolic syndrome.

【作者】

：

Hao Jiang Yuhao Wang Chunxiang Wei Xue Zhang Haochen Liu Hua He Xiaoquan Liu

【机构】

：

Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, Ch

【出处】

：

2015第11届全国药物和化学异物代谢学术会议

【发表日期】

：

2015年9期

【关键词】

：

Cardiovascular risk Diabetes Disease progression Goto-Kakizaki mini network bala

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective: Cardiovascular events still occupy the first cause of mortality in type 2 diabetes mellitus (T2DM), which comes down to the metabolic syndrome.

其他文献

尼美舒利代谢活化与肝细胞毒性研究

尼美舒利(NIM)为非甾体抗炎药,临床使用中有肝损伤的不良反应报道.其硝基还原为氨基的代谢物(NIM-NH2)在体内能氧化形成二亚胺等中间体,被认为是尼美舒利产生肝毒性的主要原因.但是,我们的前期试验表明NIM-NH2本身对原代大鼠肝细胞并无毒性.将NIM与含有NADPH和GSH的人或大鼠肝微粒体孵化后,我们共检测到两种GSH结合物：一种来源于GSH与NIM-NH2的结合(NIM-NH2-GSH)

会议

重组艾塞那肽-人血清白蛋白融合蛋白体内外代谢转化研究

目的：研究重组艾塞那肽-人血清白蛋白融合蛋白(E2HSA)在体内外的代谢特征、体内代谢转化及活性形式.方法：采用体外孵育的方法考察E2HSA在大鼠血浆、肝匀浆液、胃匀浆液、肾膜溶液中的代谢稳定性；通过建立艾塞那肽的HPLC-MS/MS定性分析方法，来检测注射E2HSA后的大鼠血清中是否有艾塞那肽形式分子的存在；采用D-半乳糖胺诱导的急性肝损伤模型、5/6肾切除所致的慢性肾衰竭模型、双侧肾结扎大鼠模

会议

Identification of Epoxide-Derived Metabolite(s) of Benzbromarone

Benzbromarone (BBR) is a benzofuran derivative that has been a quite useful drug for the treatment of gout.However, it was withdrawn from European markets in 2003, due to reported serious incidents of

会议

Effect of cholecystectomy on bile acids, enzymes and transporters in mice:Implications for pharmacok

Cholecystectomy is a traditional and effective therapeutic tool for hepatobiliary diseases whose morbidity has increased expeditiously.

会议

cholecystectomybile acidshepatic metabolic enzymestransporterspharmacokineti

Interspecies differences in systemic exposure to and metabolism of flavonoids after dosing Ginkgo bi

Aim: The flavonols are believed to be the pharmacologically active ingredients of ginkgo biloba extract and show a wide variety of biological activities.

会议

Ginkgo bilobaflavonoidssystemic exposuremetabolisminterspecies differences

In Vitro Evaluation of Bavachin as an Inhibitor of Human Liver Cytochrome P450 Enzymes

Chemical of herbal products may cause unexpected toxicity effect by the potential for alteration of the activity of human cytochrome P450 enzymes (CYP450s) when co-administered with other drugs.

会议

BavachinHerb-drug interactionsCytochrome P450isoformsInhibitionIn vitro

Metabolic activation of corynoline in vitro and in vivo

Corynoline is a 1,3-benzodioxole-containing isoquinoline alkaloid isolated from Corydalis bugeana Turcz., a traditional herbal medicine.

会议

Sulfation of Melatonin: enzymatic characterization, differences of genders,organs and species, and b

Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes.In metabolism pathways of Mel,6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the mo

会议

melatoninsulfationspecies differencesgendersanti-inflammatory

基于胆汁酸代谢调控/STAT3通路的茵栀黄抗胆汁淤积型肝损伤的分子机制

考察茵栀黄复方中抗胆汁淤积的主要药效成分，从胆汁酸代谢/炎症通路角度探讨其抗胆汁淤积性肝损伤作用的新机制。选用雄性健康129S/V小鼠，分成正常对照组、ANIT诱导模型对照组、绿原酸组、栀子苷组、黄芩苷组、滨蒿内酯组，采用液相色谱-质谱多反应监测技术开展茵栀黄复方注射液多组分血浆药动学轮廓分析和系统暴露测量；同时检测肝功能、肝组织病理学变化、胆汁酸代谢相关基因和炎症相关基因的mRNA表达及炎症相关

会议

茵栀黄血浆暴露胆汁酸代谢炎症反应肝内胆汁淤积

Effect of Berberine on Promoting the Excretion of Cholesterol in High-Fat Diet-Induced Hyperlipidemi

Objective: This study aimed to investigate the action of BBR on the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.

会议

berberinecholesterolhyperlipidemiamechanismexcretionbile

Does improved glucose control lower cardiovascular risk?A research with mini network balance model i

与本文相关的学术论文