【摘 要】
：
Bis(7)-tacrine [bis(7)-tetrahydroaminacrine],a dimeric acetylcholinesterase (AChE) inhibitor,is composed of two tacrine molecules linked by a heptylene chai
【机 构】
：
School of Electronics and Informatics engineering, South-Central University for Nationalities, Wuhan
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Bis(7)-tacrine [bis(7)-tetrahydroaminacrine],a dimeric acetylcholinesterase (AChE) inhibitor,is composed of two tacrine molecules linked by a heptylene chain.Bis(7)-tacrine is more potent (up to 150-fold) and more selective (around 250-fold) to inhibit AChE,than tacrine,one of the first-generation anticholinesterasic drugs for palliative treatment of Alzheimers disease (AD).Our recent work showed that bis(7)-tacrine inhibited both delayed rectifier potassium channel in rat DRG neurons and Kv1.2 encoded potassium channel expressed in Xenopus oocytes.In the present work,we have investigated the actions of bis(7)-tacrine on KV4.2 encoded potassium channels expressed in oocytes of Xenopus and transient A-type potassium channel in rat dorsal root ganglion (DRG) neurons.
其他文献
目的 通过脑室注射脂多糖激活脑内炎症反应,观察脑内炎症变化情况,大鼠行为学改变,以及对黑质多巴胺能神经元的影响.方法 250-300g雄性SD大鼠,侧脑室(前囟后0.8 mm,旁开1
Stroke is one of the major causes of death and seriously affects the quality of life,however,there is still no effective neuroprotective agent available in
The paper studied the change of land use and its impact on soil quality and then predicted the change of land use and cover in structure and space.Based on
柿子在我省栽培历史悠久,但甜柿栽培面积很少,我乡1991年从浙江省引进试种100多亩,1995年开始挂果,种植示范成功,产量高,效益好。日本甜柿的特性为树性强健,枝梢粗大,有开张
Objective Alzheimers disease (AD) is characterized by overproduction of β amyloid peptides (Aβ) in the brain with progressive loss of neuronal cells.Some
芦笋茎枯病是芦笋主要病害,较广泛发生在我国芦笋产区,为害严重,导致茎枝发黄、枯死,降低产量和品质,甚至全园毁灭,为了给笋农提供可选择使用的新型杀菌剂,以便轮换使用,延
蔡鹤汀先生(1909-1976)是中国近代绘画史上一位杰出的绘画大家,他的艺术成就对后人产生了深远的影响。蔡鹤汀先生是福州人,字颐园,又号枕石散人。幼喜绘画,在童年时就被周围
子宫移植怀胎不是梦因子宫有先天或后天缺陷而无法生育,一直是部分女性的终生憾事。日前,瑞典哥德堡大学产科和妇科系主任马茨?布伦斯特伦教授宣称,他们的团队已经找到了成功
【摘 要】光分路器是光纤链路中重要的无源器件之一，是具有多个输入端和多个输出端的光纤汇接器件， 在光传输过程中起着很重要的作用。铁通新疆公司利用光分路器实现了流量监控、内容监控等各种业务功能。 【关键词】光分路器；流量监控 1.光分路器的介绍 1.1光分路器的定义 光分路器是把光信号进行分路/合路的光纤无源器件，一般是对同一波长的光信号进行分离或者合路。 光分路器在光传输过程中属于无源器
目的:调查髋关节置换患者的正念心理特质、家庭关怀度及康复依从性现状，探讨髋关节置换患者正念心理特质、家庭关怀度与康复依从性间的内在关联，明确正念心理特质的中介效应。