From High Throughput Protein Micro Chip toward Single Protein Molecule Array

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户:tianzhiziyao
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  Protein microarrays have been employed to screen tens to thousands of proteins simultaneously for the observation of the biochemical activities in the protein-protein,protein-nucleic acid and small molecule interactions.This technology allows high throughput analysis and holds great potential for basic molecular biology research,disease marker identification,toxicological response profiling and pharmaceutical target screening.However,proteins easily malfunction in harsh environments so that they are hardly preserved before the application because of their complex and fragile structures.On the other hand,identify scarce amount of proteins less than fM range is very important and challenge for disease diagnosis at very early stage.
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