论文部分内容阅读
SIP/CacyBP Promotes Autophagy by Regulating Levels of BRUCE/Apollon,which Stimulates LC3-I Degradati
【机 构】
:
北京师范大学
【出 处】
:
中国生物化学与分子生物学会2019年全国学术会议
【发表日期】
:
2019年10期
其他文献
Dichloroacetate enhances the anti-tumor effect of Pirarubicin via ROS-JNK pathway in liver cancer ce
Liver cancer is one of the most common malignancies with high recurrence rate.Besides radiotherapy and surgery,chemotherapy also plays an important role in the treatment of liver cancer.
IL-17B/IL-17RB signaling regulates lysine 63-linked Beclin-1 ubiquitination to strengthen self-renew
Cancer stem cells(CSCs)display many malignant biological traits including tumorigenesis,metastasis,drug resistance and angiogenesis.
肿瘤抑癌基因p53被称为“细胞的看门人”或“基因组卫士”.在多种细胞损伤应激反应中,p53基因通过引起细胞周期阻滞和细胞凋亡维持基因组稳定性.p53的翻译后修饰是调控p53活性的重要机制之一.泛素化、磷酸化、乙酰化是主要的修饰方式,其中泛素化对p53的调控发挥中心作用.
铁储藏蛋白(Ferritin)是生物机体内调控铁离子代谢的重要蛋白。人源铁储藏蛋白通过形成稳定的球状24聚体实现铁离子高效贮存和转运,从而完成维持生物体系铁代谢平衡的重要功能。作者通过设计和调控特定区域的氨基酸序列实现了铁蛋白从球形24聚体到8聚体纳米环状结构的重新装配,利用上海光源解析了其原子分辨率的结构,在晶体结构中其呈现纳米管状堆积和长程有序排列。
Antibacterial autophagy(xenophagy)is an important host defense,but how it is initiated is unclear.Here we performed a bacterial transposon screen and identified a T3SS effector SopF that potently bloc
甲状腺癌是常见的内分泌系统肿瘤。据统计,在过去30年中,甲状腺癌在全球的发病率不断上升,在所有恶性实体肿瘤中增长速度最快,严重影响病人生活质量并带来巨大的经济及心理负担。其中甲状腺未分化癌是人类甲状腺癌相关死亡的主要原因,而且目前的医治方法大多收效甚微。
Cyanobacteria are the most abundant photosynthetic microorganisms,the global distribution of which are mainly regulated by the corresponding cyanophages.
Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosyl
Thymine DNA glycosylase(TDG)is a DNA repair enzyme that excises a variety of mismatched or damaged nucleotides(nt),e.g.,dU,dT,5fC,and 5caC.