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  5. Cross Talk Between Poly(ADP-ribose) Polymerase 1 Methylation and Oxidative Stress Involved in the To

Cross Talk Between Poly(ADP-ribose) Polymerase 1 Methylation and Oxidative Stress Involved in the To

来源 :首都医科大学第三届研究生学术论坛 | 被引量 : 0次 | 上传用户：xuelin_1985
【摘 要】
：
Given the tremendous growth in the application of titanium dioxide nanoparticles(TNPs), concerns about the potential health hazards of TNPs to humans have been raised.Poly(ADP-ribose) polymerase 1 (PA
【作 者】
：
Wenlin Bai Yujiao chen Ai gao 
【机 构】
：
Department of Occupational health and environmental health, school of Public health;Beijing Key labo
【出 处】
：
首都医科大学第三届研究生学术论坛
【发表日期】
：
2015年9期
【关键词】
：
titanium dioxide nanoparticles PARP-1 oxidative stress DNA methylation 
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　　Given the tremendous growth in the application of titanium dioxide nanoparticles(TNPs), concerns about the potential health hazards of TNPs to humans have been raised.Poly(ADP-ribose) polymerase 1 (PARP-1), a highly conserved DNA-binding protein, is involved in many molecular and cellular processes.Limited data demonstrated that certain nanomaterials induced the aberrant hypermethylation of PARP-1.However, the mechanism involved in TNP-induced PARP-1 abnormal methylation has not been studied.
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