【摘 要】
：
研究背景:B细胞通过自身表面的特异性B细胞受体(BCR)识别外源抗原,活化并启动B细胞内部信号转导通路.与可溶性抗原对B细胞刺激活化方式不同的是,依托于抗原呈递细胞(APC)表面的膜呈递抗原可以更高效的活化刺激B细胞,并诱导B细胞在抗原支持面上发生先扩张后收缩的两相性反应(first spread over the antigen bearing membrane and then contrac
【机 构】
：
清华大学生命科学学院 清华大学医学院
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
研究背景:B细胞通过自身表面的特异性B细胞受体(BCR)识别外源抗原,活化并启动B细胞内部信号转导通路.与可溶性抗原对B细胞刺激活化方式不同的是,依托于抗原呈递细胞(APC)表面的膜呈递抗原可以更高效的活化刺激B细胞,并诱导B细胞在抗原支持面上发生先扩张后收缩的两相性反应(first spread over the antigen bearing membrane and then contract),成为B细胞识别膜联抗原活化早期的标志性形态学事件.通过扩张反应,B细胞最大可能探知并接触抗原,完成BCR对抗原的识别结合以及BCR的寡聚化,随后收缩反应将BCR-抗原复合物收集到局域化的特定区域,形成BCR受体与抗原互作以及活化信号连续触发的免疫突触.
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