基于阿维菌素控制释放功能性聚合物的制备及其性能研究

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阿维菌素是一种新型、高效、高选择性、安全的农畜两用类药物,已在国内外得到广泛应用。然而,阿维菌素具有遇光易分解、半衰期短、剂型在靶标上停留时间短等缺点,本研究针对以上问题,通过功能高分子材料的设计和制备,开创性地发现了聚多巴胺具有自引发光接枝光聚合(SIPGP)的特性,结合多巴胺容易氧化自聚合成膜和粘附性特点,制备了具有紫外屏蔽性能、在不同界面都具有良好粘附性能且可以控制释放的三种新型阿维菌素剂型,利用可生物降解和环境友好型水凝胶的特点,结合阿维菌素本身具有的特征,制备了具有水、pH和温度响应性的阿
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