Africa and China relationship was formally established in the 1950s but trade and cooperation date back over 100 years. Recently, as China’s economy has continued to grow and transform the country into a major global player in all spheres, it has become clear that China increasingly needs to secure reliable sources of resources to support its economic development. Westerns investors have long labeled Africa as risky, unsafe and backward; but it has also been attractive to so called adventurous as can provide very lucrative returns and profits. African leaders are consciously recognized the difficulty and discriminatory obstacles unfairly lay in front of them by western countries (former colony masters) that impede Africa development for decade. As such, and in this new era of globalization, Africa in particular West Africa countries, are looking for a reliable trade and economy partner to enhance its development in a respectful manner. China rise offered an opportunity for a balanced and respectful trade and economy relationship with West African Countries that dignify mutual respect on win-win basis. Traditionally energy, oil, and other raw materials represent the most attractive and immediate business opportunities in Western Africa, but nowadays Africa market as diversified, consumer demand is going high and social demand of manufacturing products is also on rise, especially the demand of locally manufactured products; therefore investment on manufacturing, infrastructure development, supplies and services are also very important part of Africa-China relationship. These areas of investment provide new opportunities for Africa-China cooperation, and could form the pillar of Chino-Africa cooperation in near future.The main obstacles that confront both sides could be summarized as follow:China distance long way from West-Africa, the buying power of many African countries remain low in comparison with western countries, because of history African are more familiar with European products although are expensive but with reliable quality; Chinese manufacturing products are new in the market but welcomed because are cheaper in a reasonable quality.Notwithstanding the complexity of doing business in Africa, the impact that China’s modernization and driving need for resources can have on Africa can take the form of trade, FDI, etc. Over the past decades, China has become an influential player in Africa’s economy and development, not quite successful economic experimentation and more recent rapid market-based development; China is unique position to understand the challenges and complexities facing Africa.In doing business in Africa and establishing a development framework, one is confronted with many options.This type of engagement between Africa and China can provide valuable lessons for Africa’s development. The thesis focus to investigate the historical context of the Africa and China Cooperation (FOCAC); the need for a strategic agenda and the role NEPAD could play in this friendly but challenging Afro-Chinese relationship. Understanding of these issues can help promote business relationships that will enhance the long-term sustainable development in Africa as well as China.