癌性恶病质以短期内体重下降、脂肪及肌肉消耗为临床特征,此外还有厌食、低血糖、水肿、衰竭等。近年研究发现,引起恶病质的主要原因为代谢异常、宿主免疫系统产生致炎细胞因子、体循环中肿瘤产生的分解代谢因子等。全文就癌性恶病质发生发展机制的研究进展作一综述。 Cancerous cachexia in the short term weight loss, fat and muscle consumption as a clinical feature, in addition to anorexia, hypoglycemia, edema, failure and so on. In recent years, studies have found that the main cause of cachexia is metabolic abnormalities, the host immune system produce proinflammatory cytokines, systemic catabolism of tumor cells and so on. The article reviews the research progress on the mechanism of cancer cachexia.