用小白鼠40只,分成4组,每组10只。①组为正常对照组;②、③、④组用链佐霉素作腹腔注射。测定注射前、后小鼠空腹血糖含量。待血糖升高稳定后;④组用舒糖宝口服液灌胃治疗;③组为标准药物对照组,给盐酸二甲双胍灌胃;②组为模型组,与①组均用等体积的生理盐水灌胃。结果:各组注射STZ前的空腹血糖无显著性差异,注射STZ后第7、14天空腹血糖均比注射前有明显升高,比①组(正常组)也明显升高,而注射STZ各组比较无显著差异。治疗第10、20天测定血糖,第10天尚无显著性下降,第20天,③④组显著性下降,接近正常水平,第②组尚在较高水平;甘油三酯(TG)③④组显著低于②组;高密度脂蛋白中胆固醇与总胆固醇的比值,③④组也高于②组;血清NO和SOD含量②组低于③④组和①组,③④组间各指标无显著差异。结论:舒糖宝口服液对STZ引起的2型糖尿病小鼠有明显的治疗作用。 40 mice were used and divided into 4 groups of 10 mice each. One group was a normal control group; group 2, 3, and 4 were intraperitoneally injected with streptozotocin. The fasting blood glucose levels of mice before and after injection were measured. After stable blood glucose level, group 4 was treated with Shuganbao Oral Liquid; group 3 was a standard drug control group and metformin hydrochloride was intragastrically administered; group 2 was a model group, and group 1 was given an equal volume of physiological saline. stomach. Results: There was no significant difference in fasting blood glucose before injection of STZ in all groups. After the injection of STZ, abdominal blood glucose in the 7th and 14th days was significantly higher than that before injection, and it was also significantly higher than in group 1 (normal group). There were no significant differences between the groups. On the 10th and 20th days after treatment, blood glucose was not significantly decreased on the 10th day. On the 20th day, the 34 group was significantly decreased, approaching the normal level, and the second group was still at a relatively high level; the triglyceride (TG) 34 group was significant. The ratio of cholesterol to total cholesterol in high-density lipoprotein was higher in group 34 than in group 2. Serum NO and SOD levels were lower in group 2 than group 34 and group 1. There was no significant difference among the 34 groups. Conclusion: Shu Tang Bao Oral Liquid has obvious therapeutic effect on STZ-induced type 2 diabetic mice.