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本文从５，７－ＤＨＴ损伤的海马中制备了一种提取液，并测定了提取液对小脑内移植的胚胎５－ＨＴ神经细胞存活和生长的影响，结果显示１：２００烯释的提取液能显著增加神经细胞的存活率、神经纤维密度和５－羟色胺及５－羟哚乙酸的水平，同时移植区也明显增大，但１：１稀释的提取液对移植的中缝核神经细胞促进作用不明显。实验结果表明：①去５－ＨＴ神经的海马提取液含有某种海马释放的物质，属于损伤诱发的内源性物质。②该营养物质可直接或间接地促进５－ＨＴ神经元的生长和促进５－ＨＴ神经递质的合成与代谢。③高浓度提取液中可能存在某种抑制５－ＨＴ神经元生长的因子。
In this paper, an extract was prepared from 5,7-DHT injured hippocampus and the effect of extract on the survival and growth of embryonic 5-HT neurons implanted in cerebellum was measured. The results showed that the extract Can significantly increase the survival rate of nerve cells, nerve fiber density and 5-hydroxytryptamine and 5-hydroxyacetic acid levels, while also significantly increased graft area, but the 1: 1 dilution of the transplantation of the nucleus accumbens nerve cells promote the role Not obvious. The experimental results show that: ①The hippocampus extract to 5-HT nerve contains some substance released by some hippocampus, which belongs to the endogenous substances induced by injury. ② The nutrients can directly or indirectly promote the growth of 5-HT neurons and promote the synthesis and metabolism of 5-HT neurotransmitters. ③ high concentrations of extract may exist some inhibition of 5-HT neurons growth factor.