目的:探讨不同剂量孕激素治疗无排卵型月经失调的临床效果,为今后的临床工作提供借鉴。方法:在我院收治的无排卵型月经失调患者中,抽取160名确诊病例,随机分为4组,分别口服100mg/d,200mg/d,300mg/d,400mg/d的黄体酮进行治疗,持续10天,这4组分别为A组,B组,C组和D组。比较四组患者的撤药性出血率,并将四组患者在就诊时与月经干净后3d后的子宫内膜厚度进行对比,记录药物不良反应。结果:4组患者采取不同剂量的黄体酮进行治疗,均有较好的疗效,且疗效的差异无统计学意义;4组患者的撤药性出血率无显著差异(P>0.05);治疗前后,4组患者的子宫内膜厚度差异不大,无统计学意义;4组患者的不良反应发生率分别为5%,10%,10%和15%。其中,A组患者与D组患者差异显著,具有统计学意义(P<0.05)。结论:不同剂量孕激素治疗无排卵型月经失调的临床疗效差异不大,而较低的剂量引发的不良反应较小。 Objective: To investigate the clinical effects of different doses of progesterone in treatment of anovulatory menstrual disorders and provide references for future clinical work. Methods: 160 cases of anovulatory menstrual disorders admitted to our hospital were randomly divided into 4 groups and treated with 100 mg / day, 200 mg / day, 300 mg / day and 400 mg / day progesterone respectively. For 10 days, the four groups were Group A, Group B, Group C and Group D, respectively. The withdrawal bleeding rate was compared between the four groups. The four groups of patients were compared with the thickness of the endometrium after 3 days of menstruation, and the adverse drug reactions were recorded. Results: The four groups of patients received different doses of progesterone for treatment, which had good curative effect with no significant difference in curative effect. There was no significant difference in withdrawal bleeding between the four groups (P> 0.05). Before and after treatment, There was no significant difference in endometrial thickness between the 4 groups. There was no statistically significant difference in the endometrial thickness between the 4 groups. The incidence of adverse reactions in the 4 groups was 5%, 10%, 10% and 15% respectively. Among them, patients in group A and group D had significant differences, with statistical significance (P <0.05). Conclusion: The clinical efficacy of different doses of progesterone in treatment of anovulatory menstrual disorders is not significant, but the adverse reactions caused by lower doses are less.