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1目的 探讨 P5 3蛋白表达与皮肤基底细胞癌的临床及组织学特征之间的关系 ,以期阐明皮肤基底细胞癌的发病机制 ,为临床诊疗提供理论依据。2方法 42例经常规石蜡包埋皮肤基底细胞癌标本 ,镜检确定组织学类型 ,应用免疫组织化学 S- P法检测 P5 3蛋白表达。 3结果 42例皮肤基底细胞癌中 ,18例 P5 3蛋白表达阳性 ,阳性表达率为 42 .85 % ;9例强阳性 ,强阳性表达率为 2 1.40 % .P5 3蛋白表达与皮肤基底细胞癌的组织学类型无关(χ2 =1.38,P>0 .0 5 )。 4结论 P5 3蛋白表达与皮肤基底细胞癌有着密切关系 ,在其发病中起着重要作用。
1 Objective To investigate the relationship between the expression of P53 and the clinical and histological features of basal cell carcinoma of the skin in order to clarify the pathogenesis of basal cell carcinoma of the skin and to provide a theoretical basis for clinical diagnosis and treatment. 2 Methods 42 cases of paraffin-embedded skin basal cell carcinoma specimens were routinely examined by histological examination. The expression of P53 protein was detected by immunohistochemical S-P method. 3 results 42 cases of skin basal cell carcinoma, 18 cases of P5 3 protein positive, the positive expression rate was 42.85%; 9 cases strongly positive, strong positive expression rate of 2. 140% .P5 3 protein expression and skin basal cell carcinoma (Χ2 = 1.38, P> 0.05) regardless of histological type. 4 Conclusions P5 3 protein expression is closely related to cutaneous basal cell carcinoma and plays an important role in its pathogenesis.