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目的 :探讨吲达帕胺对老年单纯收缩期高血压 (ISH)的疗效及其对代谢的影响。方法 :10 2例老年ISH患者随机分为吲达帕胺治疗组 (n =5 2 ,吲达帕胺 1.2 5～ 2 .5mg/d)和非洛地平治疗组 (n =5 0 ,非洛地平 5～ 15mg/d)。每 1～ 2周测量坐位血压 1次。治疗前和治疗后 2个月后分别检测空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯。结果 :两组治疗前后降压疗效差异均有非常显著性意义 (P <0 .0 1) ,但组间相比差异无显著性意义 (P 0 .0 5 )。两组治疗前后空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯亦无统计学差异。结论 :吲达帕胺治疗老年ISH安全、有效 ,对空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯无明显不良影响 ,是治疗老年ISH的第一线药物
Objective: To investigate the effect of indapamide on senile isolated systolic hypertension (ISH) and its effect on metabolism. Methods: A total of 102 elderly ISH patients were randomly divided into indapamide group (n = 52, indapamide 1.2 5 ~ 2.5mg / d) and felodipine treatment group (n = 50 The level of 5 ~ 15mg / d). Measurement of sitting blood pressure every 1 to 2 weeks 1. Fasting blood glucose, blood lipids, serum uric acid, serum creatinine, serum potassium, sodium and chloride were measured before treatment and 2 months after treatment. Results: There were significant differences in the antihypertensive effect between the two groups before and after treatment (P <0.01), but there was no significant difference between the two groups (P 0 .0 5). Fasting blood glucose, blood lipids, serum uric acid, serum creatinine, serum potassium, sodium and chloride in the two groups before and after treatment were also not statistically different. CONCLUSION: Indapamide is safe and effective in the treatment of elderly ISH and has no adverse effects on fasting blood glucose, blood lipid, serum uric acid, serum creatinine, serum potassium, sodium and chlorine. It is the first-line drug for the treatment of elderly ISH