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作者用细胞化学方法检查了21例慢粒患者及11例健康人的骨髓幼稚及成熟中性粒细胞的过氧化物酶、酸性磷酸酶、碱性磷酸酶、氯醋酸酯酶、非特异性酯酶,以及脂肪、DNA. RNA、糖原的含量,将测得的结果与白血病的预后做了比较。结果发现,在恶化期间幼稚细胞的糖原、脂肪、过氧化物酶、氯醋酸酯酶、非特异性酯酶、DNA、RNA的平均细胞化学指数与健康人没有实质上的区别。酸性磷酸酶活性超过正常人许多倍,且病情愈重活性愈高。在恶化时酸性磷酸酶反应阳性的幼稚细胞百分数增加7.7倍,糖原阳性细胞增加1.6倍,过氧化物酶降低1.6倍。在病情好转时原粒细胞化学的特点和强度以及阳性率仍与恶化时一样。
The authors used cytochemical methods to examine the peroxidase, acid phosphatase, alkaline phosphatase, chloroacetate, and non-specific esterase in bone marrow naive and mature neutrophils in 21 patients with chronic granuloma and 11 healthy individuals. As well as the content of fat, DNA, RNA, and glycogen, the measured results were compared with the prognosis of leukemia. As a result, it was found that the average cell cycle index of glycogen, fat, peroxidase, chloroacetate esterase, non-specific esterase, DNA, and RNA of naive cells was not substantially different from that of healthy individuals during the deterioration period. The activity of acid phosphatase is many times higher than that of normal people, and the higher the disease is, the higher the activity is. The percentage of naive cells positive for acid phosphatase was 7.7-fold higher, glycogen-positive cells 1.6-fold, and peroxidase 1.6-fold. When the condition improves, the characteristics and intensity of positive myeloid chemistry and the positive rate are still the same as when they deteriorated.