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目的观察贝那普利联合阿托伐他汀钙片治疗高血压合并冠心病的临床效果。方法选择医院收治的高血压合并冠心病患者224例,随机分为对照组和联合组各112例,对照组使用贝那普利治疗,联合组在对照组的基础上加用阿伐他汀钙片治疗。治疗8周后,比较2组临床疗效、治疗前后血压水平变化以及心绞痛和心肌梗死发生率。结果联合组总有效率为93.75%,高于对照组的81.25%(P<0.05);治疗后,2组SBP、DBP水平相比治疗前均显著降低(P<0.05);且联合组治疗后较对照组改善更加显著(P<0.05);治疗后,2组心绞痛发生率、心肌梗死发生率均显著低于治疗前(P<0.05);且联合组治疗后较对照组显著降低(P<0.05)。结论应用贝那普利联合阿托伐他汀钙片治疗高血压合并冠心病患者,可以明显地改善患者的血压水平,取得显著的临床效果,明显降低心绞痛和心肌梗死等不良心血管事件发生率,值得在临床上推广应用。
Objective To observe the clinical effect of benazepril combined with atorvastatin calcium in the treatment of hypertension and coronary heart disease. Methods A total of 224 patients with hypertension and coronary heart disease admitted to the hospital were randomly divided into control group and combination group with 112 cases each. The control group was treated with benazepril, and the combined group was given atorvastatin calcium tablets treatment. After 8 weeks of treatment, the clinical efficacy, the changes of blood pressure before and after treatment and the incidence of angina pectoris and myocardial infarction were compared between the two groups. Results The total effective rate in the combination group was 93.75%, which was higher than that in the control group (81.25%, P <0.05). After treatment, SBP and DBP levels in both groups were significantly lower than those before treatment (P <0.05) (P <0.05). After treatment, the incidence of angina pectoris and myocardial infarction in both groups were significantly lower than those before treatment (P <0.05), and were significantly lower in the combination group than those in the control group (P < 0.05). Conclusion The application of benazepril combined with atorvastatin calcium in patients with hypertension complicated with coronary heart disease can significantly improve the patient’s blood pressure level and achieve significant clinical effects and significantly reduce the incidence of adverse cardiovascular events such as angina pectoris and myocardial infarction. Worthy of clinical application.