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利用链脲佐菌素(STZ)建立2型糖尿病大鼠模型,随机分为糖尿病模型组、二甲双胍组及葛脾煎剂组,并设置正常对照组。检测TNF-α、8-iso-PGF2α等。结果高脂高糖喂养后注射STZ建立的糖尿病大鼠模型符合2型糖尿病,葛脾煎剂能够改善2型糖尿病大鼠“三多一少”等基本状况;血糖、血脂、24h尿蛋白定量及TNF-α的水平明显改善(P<0.05),强度与二甲双胍组相似。胰岛素抵抗明显改善(P<0.05),但弱于二甲双胍组(P<0.05)。结论葛脾煎剂有降低血糖作用,但比二甲双胍弱;可以减少24h尿蛋白,降低TNF-α及8-iso-PGF2α的水平,改善胰岛素抵抗。
Streptozotocin (STZ) was used to establish a rat model of type 2 diabetes, which was randomly divided into diabetes model group, metformin group and Gepi decoction group, and normal control group was set up. Detect TNF-α, 8-iso-PGF2α and so on. Results Diabetic rat model established by injection of STZ after high-fat and high-sugar feeding was consistent with type 2 diabetes. Gepi decoction could improve the basic conditions of type 2 diabetes rats such as “three more and one less”; blood glucose, blood lipid, 24h urinary protein Quantitative and TNF-α levels were significantly improved (P<0.05), and the intensity was similar to that of metformin group. Insulin resistance was significantly improved (P<0.05) but weaker than metformin group (P<0.05). Conclusion Gepi decoction can reduce blood glucose, but it is weaker than metformin. It can reduce 24-hour urinary protein, decrease TNF-α and 8-iso-PGF2α levels, and improve insulin resistance.