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分析了52例急性髓系白血病(AML)患者的血浆总胆固醇(T-chol)水平,发现初发患者的血浆T-chol水平明显低于正常对照组,并与外周血白细胞数和白血病细胞所占比例呈负相关,单核细胞型AML患者血浆T-chol水平最低,经治疗完全缓解后血浆T-chol浓度明显上升。表明AML的低胆固醇血症与肿瘤细胞负荷和肿瘤细胞亚型有关。
The level of plasma T-chol in 52 patients with acute myeloid leukemia (AML) was analyzed. The level of plasma T-chol in the newly diagnosed patients was significantly lower than that in the normal control group. The level of leukocyte and leukemia cells The proportion was negatively correlated with the lowest level of plasma T-chol in patients with monocytic AML, and the plasma T-chol concentration was significantly increased after complete remission. It shows that hypocholesterolemia in AML is related to tumor cell load and tumor cell subtype.