为建立大肠癌根治术后肝转移动物模型，在裸小鼠脾内注入人结肠癌细胞，５ｍ ｉｎ 后切除脾脏。术后第３０ 天发现肝转移率为１００％ ，肝外其它脏器未见转移结节，组织学证实肝转移结节为低分化腺癌。结果表明本法可成功地建立裸小鼠人结肠癌肝转移模型 To establish an animal model of liver metastasis after radical operation of colorectal cancer, human colon cancer cells were injected into the spleen of nude mice and the spleens were excised 5 minutes later. On the 30th day after operation, the rate of liver metastasis was 100%. No metastatic nodules were found in other organs of the liver. The histologically confirmed liver metastasis was poorly differentiated adenocarcinoma. The results show that this method can successfully establish a model of human liver metastasis of human colon cancer