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目的 对比各种常用抑酸剂对十二指肠溃疡出血患者胃酸的抑制效果。方法 运用随机、开放的方法分析５０ 例十二脂肠溃疡出血患者，分别使用奥美拉唑静脉滴注、法莫替丁静脉注射、雷尼替丁静脉注射、西咪替丁静脉注射或滴注。持续监测患者２４ 小时胃内ｐＨ 动态变化的情况、不同胃内ｐＨ值持续时间的百分率、２４ 小时平均胃内ｐＨ 和中位ｐＨ 值。结果 只有奥美拉唑８０ｍｇ／天组可达到胃内平均ｐＨ 和中位ｐＨ 均＞６ ，法莫替丁８０ｍｇ／天组可达到胃内平均ｐＨ 和中位ｐＨ 均＞ ４，其他治疗组均未达到ｐＨ＞ ４ 。２４ 小时胃内ｐＨ＜ ４ 、ｐＨ＜ ５、ｐＨ＜ ６ 时间所占百分比依次递增为：奥美拉唑８０ｍｇ／天组、法莫替丁８０ｍｇ／ 天组、雷尼替丁２００ｍｇ／天组、西咪替丁８００ｍｇ／天组。各Ｈ２ 受体拮抗剂组与奥美拉唑静脉滴注组比较，差异均有显著性。结论 静脉使用质子泵抑制剂的抑酸效果明显优于Ｈ２ 受体拮抗剂，尤其是奥美拉唑静脉滴注胃内ｐＨ 提高持续的时间较长。
Objective To compare the inhibitory effects of various antacids on gastric acid in patients with duodenal ulcer hemorrhage. Methods A randomized and open method was used to analyze 50 cases of bleeding in patients with 12-lipopericardium ulcer. The patients were treated with omeprazole intravenous drip, famotidine intravenous injection, ranitidine intravenous injection, cimetidine intravenous injection or dripping Note. Patients were monitored continuously for changes in gastric pH within 24 hours, percentages of different gastric pH durations, mean 24-hour intragastric pH, and median pH. Results Only omeprazole 80mg / day group can reach the average gastric pH and median pH> 6, famotidine 80mg / day group can reach the average gastric pH and median pH> 4, other treatment groups were PH not higher than 4. 24 hours gastric pH <4, pH <5, pH <6 The percentage of time increased as follows: omeprazole 80mg / day group, famotidine 80mg / day group, ranitidine 200mg / Cimetidine 800mg / day group. Each H2 receptor antagonist group and omeprazole intravenous drip group, the difference was significant. Conclusion Intravenous proton pump inhibitor has better anti-acid effect than H2 receptor antagonist, especially omeprazole intravenous infusion of gastric pH to last longer.