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为了在湖沼型血吸虫病重度流行区观察青蒿琥酯预防日本血吸虫感染的效果和优化服药方案,1996年4～11月,选择安徽省贵池市唐田乡2个村为试点,选择6～65岁村民随机配对分为青蒿琥酯组和对照组。在服青蒿琥酯前20天,先服单剂吡喹酮50mg/kg。于5月下旬口服第1剂青蒿琥酯6mg/kg,以后每半个月重复给药1次,共服10次,对照组口服相同剂型的安慰剂(淀粉),在停药后4周以粪检评价效果。结果显示,口服青蒿琥酯323人的粪检血吸虫卵阳性率为0.31％,无血吸虫急性感染发生,对照组323人的粪检血吸虫卵阳性率为9.60％,平均克粪便虫卵数(EPG)为4.00±3.50,出现急性血吸虫感染1例。用药前后对肝、肾功能、网织红细胞和心电图检查未见明显变化。结果表明在感染季节每半个月口服青蒿琥酯1次,对湖沼型重度血吸虫病流行区人群有较好的预防作用。
In order to observe the effect of artesunate against Schistosoma japonicum infection and optimize the medication regimen in the severe epidemic area of lakes and swamp schistosomiasis, from April to November 1996, 2 villages in Tangtian Township, Guichi, Anhui Province were chosen as the pilot, 65-year-old villagers randomly paired into artesunate group and control group. In the service 20 days before artesunate, the first single-dose praziquantel 50mg / kg. In late May, the first dose of artesunate 6mg / kg was given orally, and once every two weeks for a total of 10 times. The placebo (starch) of the same dosage form was orally administered to the control group. After 4 weeks of withdrawal Evaluation of fecal effects. The results showed that the positive rate of egg test of schistosomiasis in 323 man with oral artesunate was 0.31%, and no acute infection with schistosomiasis occurred. In the control group, the positive rate of eggs in schistosomiasis test was 9.60% ) Was 4.00 ± 3.50, 1 case of acute schistosome infection. Before and after treatment of liver, kidney function, reticulocyte and ECG showed no significant changes. The results showed that artesunate was given orally once every two months during the infection season, which had a good preventive effect on the population with severe schistosomiasis lakes.