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载脂蛋白E是维持人类正常脂质代谢的重要物质,是一种遗传多态性蛋白,存在于多种脂蛋白中。不同基因表型调节着体内载脂蛋白E的代谢能力及其与受体的结合能力。本文对载脂蛋白E基因多态性与调血脂药临床疗效的相关性进行综述。
Apolipoprotein E is an important substance for maintaining normal lipid metabolism in humans. It is a genetic polymorphism protein present in a variety of lipoproteins. Different gene phenotypes regulate the metabolism of apolipoprotein E in vivo and its binding ability with receptors. This article reviews the relationship between apolipoprotein E gene polymorphism and the clinical efficacy of blood lipid-lowering drugs.