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目的:研究抗纤益心浓缩丸对小鼠全血凝血时间的影响。方法:将昆明小鼠随机分为抗纤益心浓缩丸高(27.1g/kg)、低(6.8g/kg)剂量组,阿司匹林对照组(20mg/kg),空白对照组(等容量生理盐水)。各组动物于每天上午8∶00左右灌胃1次,连续灌胃3d,采用毛细管法观察各组凝血时间。结果:与空白对照组相比,抗纤益心浓缩丸高、低剂量组和阿司匹林对照组凝血时间均显著延长,差异有统计学意义(P<0.05)。结论:抗纤益心浓缩丸具有明显延长小鼠凝血时间的作用。
Objective: To study the effect of Kangxian Yixin Concentrated Pills on whole blood clotting time in mice. Methods: Kunming mice were randomly divided into two groups: high dose of anti-fibrosis pills (27.1g / kg), low dose of 6.8g / kg, aspirin (20mg / kg), blank control ). The animals in each group were orally gavaged once daily at about 8:00 a.m. for 3 days. The clotting time of each group was observed by capillary method. Results: Compared with the blank control group, the coagulation time of Kangxian Yixin Concentrated Pill high, low dose group and aspirin control group were significantly prolonged, the difference was statistically significant (P <0.05). Conclusion: Kangxian Yixin Concentrated Pills can significantly prolong the clotting time of mice.