据文献报导,长期服用氯喹的患者,往往出现骨胳肌张力减退,如咀嚼无力、四肢无力等毒性反应。严重者可出现自觉气闷、急躁不安等“氧气缺乏”的现象,但此时无紫绀,给予氧也无裨益。用依米丁治疗时常能引起心肌损害,此外还可能出现全身无力、呼吸困难等症状。这些反应,在合并使用氯喹时,更为明显。上述药物之毒性反应,类似于组织呼吸抑制及骨胳肌和心肌缺乏能量的表现,因此 According to the literature, long-term use of chloroquine patients often appear skeletal muscle tension decreased, such as chewing weakness, limb weakness and other toxic reactions. In severe cases there may be spontaneous, irritability and other “oxygen deficiency” phenomenon, but this time without cyanosis, oxygen is not helpful. Treatment with emetine can often cause myocardial damage, in addition to general weakness, dyspnea and other symptoms. These reactions, when combined with chloroquine, are even more pronounced. The toxicity of these drugs, similar to the tissue respiratory depression and skeletal muscle and myocardial lack of energy performance, therefore