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转化生长因子(transformation growth factor-β)TGF-β是一种多功能的细胞因子,在肿瘤的发生、发展以及转移中都具有重要的作用。在人类肿瘤的发展过程中,TGF-β的调控是重要因素之一。在正常细胞中,TGF-β具有抑制肿瘤的作用,而在恶性肿瘤细胞中,TGF-β则具有促进肿瘤的作用。最新的研究表明TGF-β参与调控肿瘤的发生发展以及其在肿瘤微环境中发挥重要的作用。
Transformation growth factor-β TGF-β is a multi-functional cytokine that plays an important role in tumorigenesis, development and metastasis. In the development of human tumors, TGF-β regulation is one of the important factors. In normal cells, TGF-β has a tumor-suppressive effect, whereas in malignant cells, TGF-β has a tumor-promoting effect. Recent studies show that TGF-β is involved in the regulation of tumor development and plays an important role in the tumor microenvironment.