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前列腺癌(PCa)是一种发病率高,危害性大死亡率高的疾病。流行病学调查表明,随着我国居民生活水平的改善,环境污染的加剧以及饮食结构的改变,前列腺增生(BPH)和PCa都有明显增加[1],PCa是男性最常见的癌症,是威胁50岁以上男性生命的主要癌症。由于前列腺癌早期症状隐蔽,早期诊断较困难,待确诊时患者已有不同程度的局部或远处转移,因此早期诊断将有助于生存率的提高。前腺特异性抗原(prostatespecificantigen,PSA)是诊断PCa的较好的肿瘤标志物,但PSA不具有PCa的特异性,因此寻找能较早而又准确诊断PCa的实验诊断方法尤为重要。目前,总前列腺特异性抗原(tPSA)在前列腺肿瘤学研究中的价值越来越突出。本研究通过采用电化学发光法对大连市第四人民医院2008年9月至2009年9月住院患者及健康体检男性作检测,测定血清中tPSA,以了解PSA在前列腺疾病诊断中的价值。
Prostate cancer (PCa) is a disease with high morbidity and high mortality rate. Epidemiological survey shows that with the improvement of living standards of our residents, environmental pollution and changes in diet, BPH and PCa have increased significantly [1], PCa is the most common cancer in men, is a threat Men over 50 years of life the main cancer. Due to the early symptoms of prostate cancer hidden, early diagnosis is more difficult to be diagnosed when the patient has varying degrees of local or distant metastases, so early diagnosis will help to improve the survival rate. Prostate-specific antigen (PSA) is a good tumor marker for the diagnosis of PCa, but PSA does not have the specificity of PCa. Therefore, it is particularly important to find out the experimental diagnosis method for early and accurate diagnosis of PCa. At present, the value of total prostate specific antigen (tPSA) in prostate tumor research is more and more prominent. In this study, by electrochemiluminescence method in Dalian Fourth People’s Hospital from September 2008 to September 2009 hospitalized patients and healthy physical examination for men, determination of serum tPSA in order to understand the PSA in the diagnosis of prostate disease value.