作者曾评价了羊蹄Rumex japonicus、番泻叶和芦荟中的二羟蒽醌减轻β-淀粉样蛋白诱导的神经毒性的作用。现作者又研究了该成分,即1,8-二羟基蒽醌体外对β-淀粉样蛋白、凋亡及兴奋毒素诱导的神经毒性的抑制作用。将培养的皮质细胞与β-淀粉样蛋白(25-35,30μmol/L)混合24h,可引起皮质细胞中度损伤(40％～55％),胞体皱缩,直至胞体消失。当0.5～50μmol/L二羟蒽醌与β-淀粉样 The authors have evaluated the effect of dihydroquinone in Rumex japonicus, Senna and Aloe on the reduction of beta-amyloid-induced neurotoxicity in Rumex japonicus. The present authors also studied the inhibitory effect of 1,8-dihydroxypyrene on the neurotoxicity induced by β-amyloid, apoptosis and excitotoxin in vitro. The cultured cortical cells were mixed with β-amyloid protein (25-35, 30 μmol/L) for 24 h, which caused moderate damage (40% to 55%) in the cortical cells and cell body shrinkage until the cell bodies disappeared. When 0.5-50μmol/L dihydrooxime and β-amyloid