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背景:许多流行病学、临床实验报告显示血清尿酸浓度和各种心血管和肾脏疾病,特别是高血压之间有密切联系。目前,我们还不能确定这种关系是因果还是巧合。总结:本文讨论了血尿酸浓度和生物学、病理生理学、基础和临床的关系。为此,本综述提供一些几者之间关系的见解和建议。关键信息:我们认为,在大多数情况下(特别是在原发性高血压患者),血清尿酸浓度的增加是巧合,高尿酸可作为肾脏动力学障碍的生物学标志物,血清尿酸浓度与心血管及肾功能受损程度相关。此外,应考虑到某些药物影响血尿酸浓度而导致的病理生理性紊乱。
BACKGROUND: Many epidemiological and clinical laboratory reports have shown a close relationship between serum uric acid levels and a variety of cardiovascular and kidney conditions, especially hypertension. At present, we are not yet sure whether this relationship is causal or coincidental. Summary: This article discusses the relationship between serum uric acid concentration and biology, pathophysiology, basic and clinical. For this reason, this review provides some insights and suggestions on the relationship between the few. The key message: In our opinion, an increase in serum uric acid concentration is a coincidence in most cases (especially in patients with essential hypertension), and hyperuricemia can be used as a biomarker of renal dyskinesia. Serum uric acid concentrations are associated with heart Vascular and renal impairment related. In addition, should take into account the impact of certain drugs on serum uric acid concentration caused by the pathophysiological disorders.