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目的探讨早期应用猪肺泡表面活性物质治疗晚期早产儿呼吸窘迫综合征(NRDS)的临床效果。方法选取2014年5月至2016年5月晚期早产患儿42例,依入院顺序分为对照组和观察组。观察组患儿早期给予猪肺磷脂,对照组患儿给予常规治疗,无效后给予猪肺磷脂。比较两组患儿治疗前后血氧饱和度(Sa O2)、血氧分压(Pa CO2)及p H值,并记录两组患儿症状缓解时间、机械通气时间、康复时间、心率、呼吸及不良反应指标。结果两组患儿治疗后p H值、Sa O2及Pa CO2均较治疗前提高,观察组改善幅度优于对照组,差异有统计学意义(P<0.05);观察组症状缓解时间、机械通气时间及康复时间均短于对照组,差异有统计学意义(P<0.05);两组患儿呼吸及心率均较治疗前明显改善,观察组改善水平优于对照组,差异有统计学意义(P<0.05);两组不良发应发生率比较差异未见统计学意义(P>0.05)。结论早期应用猪肺泡表面活性物质治疗晚期早产儿呼吸窘迫综合征可改善患儿血气指标,提高治疗效果,安全性好,值得临床推广。
Objective To investigate the clinical effect of early application of porcine alveolar surfactant in the treatment of respiratory distress syndrome (NRDS) in advanced preterm infants. Methods Forty-two children with preterm labor from May 2014 to May 2016 were divided into control group and observation group according to the sequence of admission. In the observation group, pulmonary phlebitis was given to the infants at the early stage, while those in the control group were given routine treatment. The blood oxygen saturation (Sa O2), Pa CO2 and p H values were compared between the two groups before and after treatment, and the symptoms relief time, mechanical ventilation time, recovery time, heart rate, respiration and Adverse reaction index. Results After treatment, the p H value, Sa O2 and Pa CO2 in both groups were significantly higher than those before treatment, and the improvement in the observation group was better than that in the control group (P <0.05). The duration of symptom relief, mechanical ventilation Time and rehabilitation time were shorter than the control group, the difference was statistically significant (P <0.05); respiration and heart rate in both groups were significantly improved than before treatment, the observation group improved better than the control group, the difference was statistically significant ( P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The early application of porcine alveolar surfactant in the treatment of respiratory distress syndrome in advanced preterm infants can improve the blood gas index in children and improve the therapeutic effect, which is safe and worthy of clinical promotion.