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目的观察肝动脉化疗栓塞术(TACE)后结合经皮穿刺注射无水乙醇术(PEI)治疗原发性巨块型肝癌的疗效。方法对21例中、晚期原发性巨块型肝癌先行TACE术治疗,术后2~3周再在CT引导下PEI 1~2次,治疗2个周期后观察AFP变化和肿块缩小率以及1、2年生存率。结果19例肿块明显缩小,其中5例肿块缩小率超过50%,所有病例术前显著增高的AFP值显著降低,其中6例降低至正常范围。本组病例1、2年累计生存率分别是65%、40%。结论联合应用TACE+PEI可以作为综合介入治疗巨块型肝癌的一种常规选择方法。
Objective To observe the curative effect of transcatheter arterial chemoembolization (TACE) combined with percutaneous puncture and injection of absolute alcohol (PEI) in the treatment of primary giant hepatocellular carcinoma. Methods Twenty-one patients with advanced primary hepatocellular carcinoma of the middle and advanced stages underwent TACE before operation. PEI was performed 1 to 2 times under the guidance of CT after 2 to 3 weeks after operation. After 2 cycles of treatment, the changes of AFP and mass shrinkage and 1 , 2-year survival rate. Results 19 cases of tumors were significantly reduced, of which 5 cases of mass reduction rate of more than 50%, all cases significantly increased preoperative AFP value was significantly reduced, of which 6 cases reduced to the normal range. The cumulative survival rate of 1 year and 2 years in this group of patients was 65% and 40% respectively. Conclusions The combination of TACE + PEI can be used as a routine method for the comprehensive interventional treatment of bulky liver cancer.