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目的了解福州地区妇女生殖道解脲支原体的感染及其药物敏感情况。方法对福州地区１５２名生殖道炎症妇女和２７３名健康妇女，采集阴道或宫颈分泌物，进行解脲支原体（Ｕｕ）培养及其对９种抗生素敏感性试验。结果生殖道炎症妇女Ｕｕ阳性率６５．１３％，健康妇女阳性率４８．３５％。由生殖道炎症妇女检出的Ｕｕ对强力霉素最敏感（７８．７９％），由健康妇女检出的Ｕｕ对阿奇霉素最敏感（１００．００％）。来自不同组妇女的两群Ｕｕ菌株对阿奇霉素、乙酰螺旋霉素、红霉素和罗红霉素的敏感率差异极显著性（４种抗生素Ｐ＜０．００１）。结论福州地区妇女的Ｕｕ感染率较高，对生殖道炎症Ｕｕ感染者治疗首选强力霉素，对无临床症状的Ｕｕ感染者治疗建议首选阿奇霉素。
Objective To understand the prevalence of Ureaplasma urealyticum infection in women’s reproductive tract in Fuzhou and its drug susceptibility. Methods A total of 152 reproductive tract inflammatory women and 273 healthy women in Fuzhou district were collected vaginal or cervical secretions and cultured with Uu and their sensitivity to 9 antibiotics. Results Uu positive rate of women with genital tract inflammation was 65.13%, and that of healthy women was 48.35%. Uu detected by women with genital tract inflammation was the most sensitive to doxycycline (78.79%) and Uu detected by healthy women was the most sensitive to azithromycin (100.00%). Two groups of Uu strains from different groups of women had a very significant difference in the susceptibilities to azithromycin, acetylspiramycin, erythromycin and roxithromycin (4 antibiotics, P <0.001). Conclusion The prevalence of Uu in women in Fuzhou is higher than that in Uu infected with genital tract inflammation, and the first-choice azithromycin is recommended for the treatment of Uu-infected patients without clinical symptoms.