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目的：探讨尼莫地平联合多奈哌齐治疗血管性痴呆患者的临床疗效。方法将60例血管性痴呆患者按照随机数字表法分为两组,每组30例,均口服尼莫地平片治疗,实验组在此基础上联合多奈哌齐治疗,观察2个月。治疗前后采用简易精神状态量表评定精神状态,蒙特利尔认知量表评定认知能力。结果治疗2个月后两组各量表评分均较治疗前显著升高(P<0.05或0.01),实验组评分均显著高于对照组(P <0.01)；实验组治疗有效率为83.3%、对照组为43.3%,实验组显著高于对照组(χ2=10.33,P <0.01)。结论尼莫地平联合多奈哌齐治疗血管性痴呆具有协同增效作用,临床效果显著,显著优于单用尼莫地平治疗。“,”Objective To explore the efficacy of nimodipine plus donepezil in the treatment of vascular de-mentia (VD).Methods Sixty VD patients were assigned to two groups of 30 ones each according to ran-dom number table,both groups took orally nimodipine,on this basis experimental group was plus donepe-zil for 2 months.Before and after treatment mental states were assessed with the Mini-mental State Exam-ination (MMSE)and cognitive abilities with the Montreal Cognitive Assessment (MoCA).Results After 2 month treatment each scale scores of both groups heightened more significantly compared with pretreat-ment (P <0.05 or 0.01 )and those were significantly higher in experimental than in control group (P<0.01);effective rate was respectively 83.3% in experimental and 43.3% in control group,the former significantly than the latter (χ2 =10.33,P <0.01).Conclusion Nimodipine plus donepezil has a syner-gism and an evident effect compared with single nimodipine in the treatment of vascular dementia.