关于氟乙酸类化合物的杀血吸虫作用,主要是由于氟乙酸进入虫体后通过致死合成抑制了顺鸟头酸酶的活力,阻断了血吸虫的有氧代谢,作者已有报道。本文进一步观察到由于转化受阻而在虫体内积聚的柠檬酸又造成了糖酵解代谢途径中的6-磷酸果糖激酶活力的抑制,口服250μg氟乙酰胺/鼠/天×2后,该酶 Fluoroacetic acid compounds on the role of schistosomiasis, mainly due to fluoroacetate into the worms after death through the synthesis of synthetic inhibition of cis-head activity, blocking the aerobic metabolism of schistosomes, the authors have been reported. This paper further observes that the accumulation of citric acid in the parasites due to obstruction of transformation resulted in the inhibition of 6-phosphofructokinase activity in the glycolysis metabolic pathway. After oral administration of 250 μg of fluoroacetamide / mouse / day × 2, the enzyme