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目的探讨低剂量克林霉素对慢性鼻-鼻窦炎患者的治疗效果。方法选取2014年6月至2016年4月经诊断为慢性鼻-鼻窦炎入院治疗的56例患者为研究对象,按双盲法随机分为对照组(19例)、观察1组(19例)和观察2组(18例)。对照组患者采用激素治疗,观察1组患者在此基础上使用低剂量克林霉素,观察2组患者使用常规剂量克林霉素,对3组患者用药后疾病治疗效果进行评估,同时对治疗前后患者面部疼痛、鼻塞、嗅觉、流涕疼痛感进行测评,统计用药所致不良反应发生情况。结果观察2组患者治疗的总有效率明显高于对照组、观察1组,且观察1组患者治疗的总有效率明显高于对照组,差异均有统计学意义(均P<0.05);治疗后,观察1组与观察2组患者面部疼痛、鼻塞、嗅觉、流涕疼痛视觉模拟量表(VAS)评分均明显低于对照组,差异均有统计学意义(均P<0.05),观察1组与观察2组患者面部疼痛、鼻塞、嗅觉、流涕VAS评分差异无统计学意义(P>0.05);观察1组患者用药治疗期间不良反应发生率明显低于对照组、观察2组,差异有统计学意义(P<0.05);对照组、观察2组患者用药治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论临床对慢性鼻-鼻窦炎患者进行治疗时,可采用激素联合低剂量克林霉素进行治疗,患者恢复效果好、症状得到有效改善,不良反应少。
Objective To investigate the therapeutic effect of low dose clindamycin on patients with chronic rhinosinusitis. Methods Fifty-six patients diagnosed as chronic rhinosinusitis admitted from June 2014 to April 2016 were randomly divided into control group (n = 19), control group (n = 19) and control group Two groups (18 cases) were observed. The control group of patients with hormone therapy, observation of a group of patients on the basis of the use of low-dose clindamycin observed two groups of patients using conventional doses of clindamycin, the three groups of patients after treatment of disease treatment to assess the effect, while treatment Before and after the patient facial pain, nasal congestion, smell, runny nose pain assessment, statistical application of adverse reactions. Results The total effective rate of the two groups was significantly higher than that of the control group. The total effective rate of the observation group 1 was significantly higher than that of the control group (all P <0.05) Visual acuity scale (VAS) of facial pain, nasal obstruction, olfactory and runny nose pain in observation group 1 and observation group 2 were significantly lower than those in control group (all P <0.05). Observation 1 There was no significant difference in VAS score between group 2 and group 2 (P> 0.05). The incidence of adverse reactions in group 1 was significantly lower than that in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups in the control group (P> 0.05). Conclusion Clinical treatment of patients with chronic rhinosinusitis can be hormone combined with low-dose clindamycin for treatment, the patient recovery effect is good, the symptoms have been effectively improved, with fewer adverse reactions.