论文部分内容阅读
作者观察了7例急性淋巴细胞白血病(ALL)、17例急性非淋巴细胞白血病(ANLL)、1例慢粒急变患者的骨髓和周围血中的尿嘧啶-DNA糖化酶活性。其中男性17例,女性8例,年龄19-78岁,9例非血液病患者作为对照组。另外还测定了白血病和淋巴瘤细胞株中的尿嘧啶-DNA糖化酶活性9例。周围血和/或骨髓的单核细胞成份中尿嘧啶-D-NA糖化酶活性测定结果为:7例(10个标本)ALL为26.6-80.8单位/毫克蛋白,17例(20个标本)ANLL为17.7-72.4单位/毫克蛋白,1例慢粒急变为44.7单位/毫克蛋白。ANLL与ALL酶的活性水平相接近((?)±SD),前者为41.1±13.8单位/毫克蛋白,后者为45.6±14.8单位/毫克蛋白,发现当单个核细胞成份中未成熟的细胞较少时,尿嘧啶-DNA糖化酶的活性较低,未成熟细胞的比例与酶活性之间呈
The authors observed uracil-DNA saccharase activity in bone marrow and peripheral blood in seven patients with acute lymphoblastic leukemia (ALL), 17 with acute non-lymphocytic leukemia (ANLL), and one with chronic myo- graying. Among them, 17 were males and 8 were females, aged 19-78 years. Nine non-hematologic patients served as control group. In addition, 9 cases of uracil-DNA saccharase activity in leukemia and lymphoma cell lines were also assayed. Uracil-D-glucosidase activity in monocytes from peripheral blood and / or bone marrow was determined as follows: ALL (26.6-80.8 units / mg protein), 17 (20 specimens) ANLL 17.7-72.4 units / mg protein, 1 case of blast crisis to 44.7 units / mg protein. The level of ANLL activity was similar to that of ALL (± (SD)), with 41.1 ± 13.8 units / mg protein for the former and 45.6 ± 14.8 units / mg protein for the latter and found that when immature cells in the mononuclear cell fraction When less, uracil-DNA saccharase activity is low, the proportion of immature cells and enzyme activity was