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自中药款冬花中分离得款冬素tussilagin,14-acetoxy-7 β-[3’ethyl crotonoloxy]-notonipetranone(Ⅰ),14-acetoxy-7 β-[3’-ethyl crotonoloxy]-1 α-[2’-methylbutylryloxy]-notonipetranone(Ⅱ),7 β-[3’-ethylcrotonoyloxy]-1 α-[2’-methylbutyryloxy]-3,14-dehydro-z-notonipetranone(Ⅲ)及β-谷留醇。(Ⅱ)(Ⅲ)皆首次从款冬花中分得。以血小板活化因子引起的血小板聚集实验测定,(Ⅰ)(Ⅱ)(Ⅲ)有抑制活性,(Ⅴ)没有活性。(Ⅰ)对钙通道阻滞剂受体结合实验有阻断活性,IC_(50)=1μg/ml。
Isolates the tacrolimus tussilagin,14-acetoxy-7 β-[3’ethyl crotonoloxy]-notonipetranone (I),14-acetoxy-7 β-[3’-ethyl crotonoloxy]-1 α-[2] from coltsfoot flowers ’-methylbutylryloxy’-notonipetranone (II), 7 β-[3’-ethylcrotonoyloxy]-1 α-[2’-methylbutyryloxy]-3,14-dehydro-z-notonipetranone (III) and β-gustryl alcohol. (II) (III) were all derived from the Coltsfoot flower for the first time. In the platelet aggregation test induced by platelet activating factor, (I) (II) (III) had inhibitory activity and (V) had no activity. (I) Blocking activity on calcium channel blocker receptor binding assay, IC 50 = 1 μg/ml.