调节性T细胞(regulatory T cells,Treg细胞)是CD4~+T细胞的亚群,具有免疫抑制功能,Foxp3是其特异性转录分子。在众多自身免疫性疾病中可发现,Treg细胞存在数量或功能的异常,如类风湿关节炎、系统性红斑狼疮、多发性骨髓瘤、再生障碍性贫血等~([1-4])。近年研究发现,Treg细胞还与疾病严重程度及预后密切相关~([5-7])。可根据Treg细胞的数量、功能评估疾病病情,从而选择合理的治疗 Regulatory T cells (Treg cells) are subsets of CD4 ~ + T cells, immunosuppressive function, Foxp3 is its specific transcriptional molecules. Among numerous autoimmune diseases, there are abnormalities in the number or function of Treg cells such as rheumatoid arthritis, systemic lupus erythematosus, multiple myeloma, aplastic anemia, etc. [1-4]. Recent studies have found that Treg cells are also closely related to the severity and prognosis of disease (5-7). According to the number of Treg cells, the function of the disease condition assessment, so as to select a reasonable treatment