An analysis of the boundary layer flow and heat transfer in a Jeffrey fluid containing nanoparticles is presented in this paper. Here, fluid motion is due to a stretchable cylinder. The thermal conductivity of the fluid is taken to be temperature-dependent. The partial differential equations of velocity, temperature, and concentration fields are transformed to a dimensionless system of ordinary differential equations. Nonlinear governing analysis is computed for the homotopy solutions. The behaviors of Brownian motion and thermophoresis diffusion of nanoparticles have been examined graphically. Numerical values of the local Nusselt number are computed and analyzed. An analysis of the boundary layer flow and heat transfer in a Jeffrey fluid containing nanoparticles is presented in this paper. Here, fluid motion is due to a stretchable cylinder. equations of velocity, temperature, and concentration fields are transformed to a dimensionless system of ordinary differential equations. Nonlinear governing analysis is computed for the homotopy solutions. The behaviors of Brownian motion and thermophoresis diffusion of nanoparticles have been examined graphically. Numerical values ​​of the local Nusselt number are computed and analyzed.