2,3-异丙亚基核糖在糖化学中有着广泛的应用,特别是在核苷的合成中占有十分重要的地位。寻找简便有效的合成方法一直受到人们的重视。经典的合成方法是在酸的催化下,令核糖与无水丙酮反应制得,但反应产物较复杂,收率较低,分离困难。60年代以来应用2,2-甲氧基丙烷作为异丙亚基化试剂的方法逐步得到了发展,但此法仍存在副产物难以分离 2,3-Isopropylidene ribose has a wide range of applications in sugar chemistry, especially in the synthesis of nucleosides. Finding simple and effective synthesis methods has always been valued by people. The classical synthesis method is that under the catalysis of acid, the ribose is reacted with anhydrous acetone, but the reaction product is more complicated, the yield is lower, and the separation is difficult. The method of using 2,2-methoxypropane as isopropylallylating agent has been developed gradually since the 1960s, but the by-product is still difficult to be separated by this method