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目的研究二氧化氯消毒剂亚急性毒性,作出生物安全性评价。方法采用动物试验法进行了实验室试验观察。结果该二氧化氯消毒剂给药量在117 mg/kg(体重)条件下,对大鼠的体重、血常规及血液生物化学等指标无异常变化,与阴性对照组比较均无显著差异(P>0.05)。病理检查发现,高剂量组个别动物肺脏切片可观察到少数组织轻度充血改变,但无组间特异性分布,同样的变化在对照组动物中也能观察到,其它脏器均无异常变化。结论二氧化氯消毒剂亚急性毒性试验组动物观察指标基本正常,少部分组织有异常变化,主要考虑为动物质量问题。因此,该消毒剂在本次实验条件下,未显示有亚急性毒性作用。
Objective To study the subacute toxicity of chlorine dioxide disinfectant and evaluate its biosafety. Methods Animal experiments were conducted in laboratory experiments. Results The dose of chlorine dioxide disinfectant at 117 mg / kg (body weight) did not show any significant changes in body weight, blood and blood biochemistry, and no significant difference compared with the negative control group (P > 0.05). Pathological examination found that high dose group of individual animal lung slices can be observed in a small number of tissue hyperemia changes, but no specific distribution between groups, the same changes in the control group animals can be observed, no abnormal changes in other organs. Conclusions The observed indicators of sub-acute toxicity test of chlorine dioxide disinfectant are basically normal and some of them have abnormal changes. The main consideration is animal quality. Therefore, the disinfectant in this experimental conditions, did not show subacute toxic effects.