建立了液固顶空气相色谱法测定双氢青蒿素中有机溶剂残留量。采用DB-5大口径毛细管柱,以正丙醇为内标进行定量。甲醇、乙醇的线性范围分别为3.2～317.0μg·mL-1(r=0.9996),3.5～348.0μg·mL-1(r=0.9995);回收率分别为104.8%,101.1%;最低检测限分别为0.08μg·g-1,0.18μg·g-1。本方法简单、准确、灵敏度及重现性好。 A liquid-solid headspace gas chromatography was developed for the determination of residual organic solvents in dihydroartemisinin. Using DB-5 large diameter capillary column, with n-propanol as internal standard for quantitative. The linear range of methanol and ethanol were 3.2-317.0μg · mL-1 (r = 0.9996) and 3.5-348.0μg · mL-1 (r = 0.9995) respectively. The recoveries were 104.8% and 101.1% 0.08 μg · g-1 and 0.18 μg · g -1. The method is simple, accurate, good sensitivity and reproducibility.