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目的分析亚低温治疗对重症颅脑损伤患者脑保护作用。方法我院神经外科的重症颅脑损伤(GCS≤8分)患者共68例,随机分为对照组和亚低温组,每组各34例。其中对照组给予常规脱水降低颅内压等治疗,亚低温组在常规治疗基础上行亚低温低温疗法。根据GOS评分对患者6个月时的神经系统进行评分,并治疗12个月后的生活质量急性评估,治疗过程中记录亚低温的副作用包括低血压、肺部感染、心动过缓及颅内高压反跳导致致死性脑疝等发生情况。结果两组患者随机分为对照组和亚低温组,各34例,两组在年龄、性别、病程及神经系统评分(GCS评分)上均无显著性差异(P>0.05),组间具有可比性。根据GOS评分对患者6个月时的神经系统进行评分,亚低温组的神经系统评分明显优于对照组(P<0.05),治疗12个月后的生活质量急性评估,亚低温组的远期生活质量明显优于对照组(P<0.05)。结论亚低温对于重度颅脑损伤患者具有明确的脑保护作用,治疗过程中无明显副作用。
Objective To analyze the protective effects of mild hypothermia on patients with severe craniocerebral injury. Methods A total of 68 patients with severe craniocerebral injury (GCS≤8) in our department of neurosurgery were randomly divided into control group and mild hypothermia group, 34 cases in each group. The control group was given conventional dehydration to reduce intracranial pressure and other treatments. The mild hypothermia group received routine hypothermia and hypothermia therapy. The patients’ neurologic status at 6 months was scored according to the GOS score and treated for an acute assessment of quality of life after 12 months. Mild hypothermia-related side effects were recorded during treatment including hypotension, pulmonary infection, bradycardia and intracranial hypertension Rebound lead to fatal hernia and other occurrences. Results The two groups were randomly divided into control group and mild hypothermia group, with 34 cases in each group. There was no significant difference between the two groups in age, sex, course of disease and neurological score (GCS score) (P> 0.05) Sex. According to the GOS score, the neurological scores at 6 months were significantly higher in the mild hypothermia group than those in the control group (P <0.05). The acute quality of life assessment after 12 months of treatment and the long-term Quality of life was significantly better than the control group (P <0.05). Conclusion Mild hypothermia has definite brain protective effect on patients with severe craniocerebral injury, and no obvious side effects during treatment.