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目的探讨瑞安市女性人乳头瘤病毒(HPV)感染情况,为HPV感染防治及干预措施制订提供理论依据。方法2012年1月-2014年1月在瑞安市人民医院体检中心及门诊做妇科体检的本地区女性居民2 625例作为研究对象,以第二代杂交捕获HPV-DNA技术(HCII)检测HPV感染情况。结果瑞安市女性HPV感染率为19.81%(520/2 625)。各年龄段HPV感染率之间差异有统计学意义(χ2=16.79,P=0.019),HPV感染率最高者为18~25岁组,其感染率达到26.15%(108/413),HPV感染率最低者为26~30岁组,其感染率为16.89%(124/734),HPV感染率年龄分布上呈现“V”字形分布。不同职业、不同民族人群的HPV感染率差异亦均有统计学意义(χ2=234.331,P=0.000;χ2=33.52,P=0.000),医务人员的感染率最低,自由职业者、服务员的感染率远高于其他人群,汉族感染率高于少数民族。结论瑞安市不同年龄、不同职业、不同民族的女性HPV感染率存在差异,应对高危人群加强HPV感染监测并普及女性卫生保健知识,从而降低宫颈癌发病率。
Objective To investigate the prevalence of human papillomavirus (HPV) infection in women in Ruian City and to provide a theoretical basis for the prevention and treatment of HPV infection and the formulation of interventions. Methods From January 2012 to January 2014, 2 625 female residents in the local gynecological examination center of Ruian People’s Hospital and outpatient department were enrolled in this study. HPV infection was detected by second-generation hybridization with HPV-DNA technology (HCII) Happening. Results The female HPV infection rate in Ruian City was 19.81% (520/2 625). The HPV infection rate among all age groups was statistically significant (χ2 = 16.79, P = 0.019). The highest HPV infection rate was between 18 and 25 years old group, and the infection rate was 26.15% (108/413). The HPV infection rate The lowest was from 26 to 30 years old, and the infection rate was 16.89% (124/734). The age distribution of HPV infection showed “V” shape distribution. HPV infection rates in different occupations and ethnic groups were also significantly different (χ2 = 234.331, P = 0.000; χ2 = 33.52, P = 0.000). The infection rate among medical staffs was the lowest, and the infection rate among freelance workers and waiters Much higher than other groups, Han infection rate is higher than that of ethnic minorities. Conclusion The prevalence of HPV infection varies among women of different ages, occupations and ethnic groups in Rui’an. It is necessary to strengthen the monitoring of HPV infection in high-risk groups and popularize the knowledge of female health care so as to reduce the incidence of cervical cancer.