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目的:研究感康宁胶囊中莪术油β-环糊精包合的工艺。方法:采用研磨法制备莪术挥发油3-环糊精(β-CD)包合物,以莪术油β-CD包合物中莪术油包合率及包合物中莪术油含量为指标进行考察。结果:β-CD与油(g/ml)的比例对莪术油包合率的影响显著,研磨时间(min)也明显,乙醇浓度(%)无显著差异,最终得到黄白色粉末装固体。结论:采用研磨法制备莪术油β-CD包合物可以很好的保留感康宁胶囊中主要有效成分莪术油的活性。
Objective: To study the inclusion of Curcuma oil β -cyclodextrin in Kang’ning Capsule. Methods: The inclusion compound of β-CD of essential oil of Rhizoma Curcumae was prepared by grinding method. The inclusion ratio of Curcuma oil in Curcuma oil of β-CD of Curcuma oil and the content of Curcuma oil in inclusion compound were investigated. Results: The ratio of β-CD to oil (g / ml) had significant effect on the inclusion ratio of Curcuma phaeocaulis. The grinding time (min) was also significant. There was no significant difference in ethanol concentration (%). Conclusion: The preparation of Curcuma oil β-CD inclusion by grinding method can well preserve the active ingredient of Curd oil, which is the main active ingredient of fluconazole.