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目的研究淋巴细胞微核四项检测指标在白血病的早期诊断及鉴别诊断中的作用。方法采用外周血改良淋巴细胞微核检测方法对326例白血病患者外周血淋巴细胞微核四项检测指标进行观察和统计分析。结果各类白血病中,L1的外周血淋巴细胞微核四项检测指标较其他白血病组明显减低,但较对照组明显增高,相互间有明显差异(P<0.01);急性髓系白血病(AML)较对照组明显增高(P<0.01),但各组之间无显著差异(P>0.05)。结论淋巴细胞微核检测方法简便、快速、准确、经济实用,比传统诊断方法早0.5a～5a年即可预测早期白血病的发生,该项指标的建立对白血病的早期诊断及鉴别诊断具有重大的临床意义。
Objective To study the role of lymphocyte micronucleus test in early diagnosis and differential diagnosis of leukemia. Methods Peripheral blood lymphocyte micronucleus test method was used to detect and statistically analyze the four items of micronucleus test in 326 leukemia patients. Results Among all kinds of leukemias, the detection index of L1 micronucleus in peripheral blood lymphocytes in L1 was significantly lower than that in other leukemia groups, but significantly higher than that in control group (P <0.01). Acute myeloid leukemia (AML) Which was significantly higher than that of the control group (P <0.01), but there was no significant difference between the groups (P> 0.05). Conclusion The detection method of lymphocyte micronucleus is simple, rapid, accurate, economical and practical, predicting the incidence of early leukemia 0.5-5 years earlier than the traditional diagnostic methods. The establishment of this index is of great importance for the early diagnosis and differential diagnosis of leukemia Clinical significance.