【摘 要】
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Dear Editor,Proline-rich antimicrobial peptides (PrAMPs) are a class of antimicrobial peptides containing a high content of proline residues.PrAMPs selectively
【机 构】
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School of Life Sciences, Tsinghua University, Beijing 100084,China“,”Tsinghua-Peking Joint Center fo
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Dear Editor,Proline-rich antimicrobial peptides (PrAMPs) are a class of antimicrobial peptides containing a high content of proline residues.PrAMPs selectively target Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm (Mattiuzzo et al.,2007).On the other hand,PrAMPs present a low toxicity to mammalian cells,because they cannot effectively penetrate the mammalian cellular membrane (Hansen et al.,2012) or they are intealized through an endocytotic process to minimize interaction with cytosolic ribosomes (Tomasinsig et al.,2006).Therefore,PrAMPs are promising candidates to treat infections and to deliver drugs (Schmidt et al.,2016).
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